QTL mapping provides new insights into emamectin benzoate resistance in salmon lice, Lepeophtheirus salmonis
Major determinants of EMB resistance in L. salmonis are located on Chromosome 5. Resistance can be predicted using a limited number of genetic markers. Genes transcriptionally up-regulated in EMB resistant parasites include a β spectrin, a cytoskeletal protein with still incompletely understood roles in neuron structure and function, as well as glutathione S-transferase, an enzyme with potential roles in the biochemical defence against toxicants.
Authors
- John B. Taggart (ORCID: https://orcid.org/0000-0002-3843-9663)
- Ross D. Houston (ORCID: https://orcid.org/0000-0003-1805-0762)
- Greta Carmona‐Antoñanzas (ORCID: https://orcid.org/0000-0003-0003-7973)
- James E. Bron (ORCID: https://orcid.org/0000-0003-3544-0519)
- Karim Gharbi (ORCID: https://orcid.org/0000-0003-1092-4488)
- Joseph L. Humble (ORCID: https://orcid.org/0000-0002-2496-4555)
- David I. Bassett (ORCID: https://orcid.org/0000-0002-7529-0829)
- Sally Boyd
- Armin Sturm (ORCID: https://orcid.org/0000-0003-2632-1999)
- Michaël Bekaert (ORCID: https://orcid.org/0000-0002-1206-7654)
- Claudia Croton
- Rapule Mphuti
Institutions
- University of Stirling (GB)
- Roslin Institute (GB)
- Earlham Institute (GB)
- Benchmark Animal Health (United Kingdom) (GB)
- Edinburgh Genomics (GB)
- Pharmaq (Norway) (NO)
- Benchmark Holdings (Norway) (NO)
- University of Glasgow (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12864-024-11096-2
- Primary Topic
- Parasite Biology and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zoetis
- Marine Alliance for Science and Technology for Scotland
- Scottish Funding Council
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council