LEP O-GlcNAcylation inactivates NF-κB pathway by suppressing LEP protein level and thus mediates cellular senescence and osteogenic differentiation in mouse mesenchymal stem cells
Our findings demonstrated that O-GlcNAcylation of LEP inactivated the NF-κB pathway by reducing LEP protein levels, thereby inhibiting cellular senescence and promoting osteogenic differentiation in C3H10T1/2 cells. This study may provide a novel therapeutic target for the treatment of osteoporosis.
Authors
- Chunxiao Zhou (ORCID: https://orcid.org/0000-0002-1257-9537)
- Lili Yu (ORCID: https://orcid.org/0000-0001-5832-1024)
- Zhuang Zhang (ORCID: https://orcid.org/0000-0001-7653-1033)
Institutions
- Macau University of Science and Technology (MO)
- Zhuhai People's Hospital (CN)
Publication Details
- Journal
- BMC Molecular and Cell Biology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12860-024-00523-7
- Citations
- 2
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.48