New insights into the role of mitophagy related gene affecting the metastasis of osteosarcoma through scRNA-seq and CRISPR-Cas9 genome editing
Our comprehensive analysis elucidated the profile of mitophagy throughout the OSA metastasis process, forming the basis for a mitophagy-related prognostic model that addresses clinical outcomes and drug sensitivity following OSA metastasis. Additionally, an online interactive platform was established to assist clinicians in decision-making ( https://mip-score.shinyapps.io/labtan/ ). These findings lay the groundwork for developing targeted therapies aimed at improving the prognosis of OSA patients.
Authors
- Mengliang Luo
- Zhengqiang Peng (ORCID: https://orcid.org/0000-0003-1165-4977)
- Jianye Tan
- Shaowei Zheng (ORCID: https://orcid.org/0009-0001-9064-8577)
- Xuanxuan Huang (ORCID: https://orcid.org/0000-0003-1427-9113)
- Sikuan Zheng (ORCID: https://orcid.org/0000-0002-3462-8547)
- Hong Huang (ORCID: https://orcid.org/0000-0001-5698-8116)
Institutions
- Central South University (CN)
- Nanchang University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Zhujiang Hospital (CN)
- Huizhou Central People's Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12964-024-01989-w
- Citations
- 7
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province