PPARβ/δ upregulates the insulin receptor β subunit in skeletal muscle by reducing lysosomal activity and EphB4 levels
Overall, these findings reveal that PPARβ/δ activation increases InsRβ levels by alleviating ER stress and lysosomal degradation.
Authors
- Jue-Rui Wang
- Walter Wahli
- Manuel Vázquez‐Carrera (ORCID: https://orcid.org/0000-0001-7138-8207)
- Ricardo Rodríguez‐Calvo (ORCID: https://orcid.org/0000-0001-7513-0983)
- Emma Barroso (ORCID: https://orcid.org/0000-0003-4551-4825)
- Antoni Camins (ORCID: https://orcid.org/0000-0002-1229-5956)
- Xavier Palomer (ORCID: https://orcid.org/0000-0001-7647-9984)
- Javier Jurado-Aguilar
Institutions
- Hospital Sant Joan de Déu Barcelona (ES)
- Instituto de Salud Carlos III (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Toxicologie Alimentaire (FR)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Universitat de Barcelona (ES)
- University of Lausanne (CH)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12964-024-01972-5
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Centres de Recerca de Catalunya
- Generalitat de Catalunya
- Universitat de Barcelona
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación