Exploring autism spectrum disorder and co-occurring trait associations to elucidate multivariate genetic mechanisms and insights
Our study, combining multivariate GWAS with systematic decomposition, identified novel genetic associations related to ASD and ASD co-occurring driver traits. Statistical tests were applied to discern evidence for shared and interpretable liability between ASD and co-occurring traits. These findings expand upon the current understanding of the complex genetics regulating ASD and reveal insights of neuronal brain disruptions potentially driving development and manifestation.
Authors
- Jake Lin (ORCID: https://orcid.org/0000-0001-9928-1663)
- Christine Ladd‐Acosta (ORCID: https://orcid.org/0000-0002-7697-3998)
- Reija Autio (ORCID: https://orcid.org/0000-0002-6519-2715)
- Alessio Fasano (ORCID: https://orcid.org/0000-0002-2134-0261)
- François Iris (ORCID: https://orcid.org/0000-0002-9384-8160)
- Christophe Roos (ORCID: https://orcid.org/0000-0003-0982-7664)
- Karoliina Salenius (ORCID: https://orcid.org/0000-0003-1104-0406)
- Niina Väljä
- Sini Thusberg
- Matti Nykter
Institutions
- Boston University (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Tampere University of Applied Sciences (FI)
- Tampere University (FI)
- Karolinska Institutet (SE)
- European Biomedical Research Institute of Salerno (IT)
- Tampere University (FI)
- Cancer Society of Finland (FI)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12888-024-06392-w
- Citations
- 8
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 2.74
Funders
- European Commission
- Tays
- Horizon 2020 Framework Programme