Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation
This study is the first to describe the involvement of KCNA2 expression and Kv1.2 channel in cancer development. The study also unveiled the involvement of KCNA2 in the regulation of the Hippo/YAP signalling cascade. Thus, this work suggests that KCNA2/Kv1.2 could be a potential therapeutic target in ES.
Authors
- Anaïs Postec (ORCID: https://orcid.org/0009-0001-1197-9838)
- Aurélie Chantôme (ORCID: https://orcid.org/0000-0002-2756-8670)
- Laura Regnier
- Marie Potier‐Cartereau (ORCID: https://orcid.org/0000-0002-1361-3397)
- François Lamoureux (ORCID: https://orcid.org/0000-0002-2738-0758)
- Christophe Vandier (ORCID: https://orcid.org/0000-0003-2559-0660)
- Mathilde Mullard
- Régis Brion
- Marc Baud’huin (ORCID: https://orcid.org/0000-0002-3357-329X)
- Franck Verrecchia (ORCID: https://orcid.org/0000-0003-4920-2554)
- Françoise Rédiní (ORCID: https://orcid.org/0000-0002-3644-7627)
- Steven Georges (ORCID: https://orcid.org/0000-0003-0804-0253)
- Philippe Hulin
- Maryne Dupuy
- Benjamin Ory (ORCID: https://orcid.org/0000-0002-2622-7356)
- Maxime Guéguinou (ORCID: https://orcid.org/0000-0002-5793-2082)
- Bénédicte Brounais-Le Royer
Institutions
- Université de Tours (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers (FR)
- Foie, Métabolisme, Cancer (FR)
- Université d'Angers (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12964-024-01981-4
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Infrastructures en Biologie Santé et Agronomie
- Ligue Contre le Cancer
- Institut National Du Cancer
- Cancéropôle Grand Ouest