Redox homeostasis of one-carbon metabolism-dependent reprogramming is critical for RCC progression under exogenous serine/glycine-deprived conditions
Our results indicate that exogenous serine/glycine are critical for RCC progression by maintaining one-carbon metabolism-dependent redox homeostasis, which provides new insights for the development of dietary serine/glycine starvation-based therapeutic approaches for RCC.
Authors
- Mengzhen Fan
- Sichang Liu
- Jiansheng Gao
- Mingxia He
- Meihua Qu (ORCID: https://orcid.org/0000-0003-2464-6773)
- Chen Liu (ORCID: https://orcid.org/0009-0003-0430-6146)
- Huijuan Wang (ORCID: https://orcid.org/0000-0002-8113-3774)
- Xiaodi Shang
- Jingying Chen (ORCID: https://orcid.org/0000-0002-2479-818X)
- Yanxin Xu (ORCID: https://orcid.org/0009-0006-0504-1524)
- Xia Li (ORCID: https://orcid.org/0000-0001-7252-6907)
- Junqing Hou
- Xin Hou (ORCID: https://orcid.org/0000-0003-4625-1692)
Institutions
- Henan University (CN)
- Kaifeng University (CN)
- Kaifeng City Children's Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12885-024-13304-4
- Citations
- 6
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Science and Technology Department, Henan Province