Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes
Our study revealed both shared and distinct, cancer-promoting functions of PEVs, which contributed to the transcriptome and metastatic capabilities of the melanoma spheroids. Inhibiting the platelet receptors that modulate the PEVs' cancer-promoting properties may open up new strategies for identifying promising treatment targets for cancer therapy.
Authors
- Pia Siljander (ORCID: https://orcid.org/0000-0003-2326-5821)
- Johannes Oesterreicher (ORCID: https://orcid.org/0000-0003-4899-3198)
- Mari Palviainen (ORCID: https://orcid.org/0000-0002-7105-3543)
- Wolfgang Holnthoner (ORCID: https://orcid.org/0000-0001-6425-9028)
- Saara Laitinen (ORCID: https://orcid.org/0000-0002-3482-1304)
- Alessandra Valéria de Sousa Faria (ORCID: https://orcid.org/0000-0003-1161-5724)
- Zeynep Tavukcuoglu (ORCID: https://orcid.org/0000-0002-3165-0108)
- Umar Butt (ORCID: https://orcid.org/0000-0002-0696-9520)
Institutions
- University of Helsinki (FI)
- Hospital Israelita Albert Einstein (BR)
- Finnish Red Cross (FI)
- Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA (AT)
- Ludwig Boltzmann Institute for Digital Health and Prevention (AT)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12964-024-01973-4
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Itä-Suomen Yliopisto
- Helsingin Yliopisto
- Helsingin ja Uudenmaan Sairaanhoitopiiri
- Medicinska Understödsföreningen Liv och Hälsa
- Cedars-Sinai Medical Center
- Magnus Ehrnroothin Säätiö
- Turun Yliopisto
- Orionin Tutkimussäätiö
- Biocenter Finland
- Helsinki Institute of Life Science, Helsingin Yliopisto