Chemogenetic Inhibition of Prefrontal Cortex Ameliorates Autism-Like Social Deficits and Absence-Like Seizures in a Gene-Trap Ash1l Haploinsufficiency Mouse Model
We demonstrated that increased neural activity in the PFC contributed to the autism-like social deficits and absence-like seizures in Ash1l<sup>+/GT</sup> mice, which provides novel insights into the therapeutic strategies for patients with <i>ASH1L</i>-associated ASD and epilepsy.
Authors
- Kaijie Ma (ORCID: https://orcid.org/0009-0009-6355-4952)
- Luye Qin (ORCID: https://orcid.org/0000-0003-3884-8165)
- Dao-Qi Zhang (ORCID: https://orcid.org/0000-0002-2942-4128)
- M. Webb
- Kylee McDaniel
Institutions
- Mount Marty College (US)
- University of South Dakota (US)
Publication Details
- Journal
- Genes
- Published
- 2024-12-18
- DOI
- https://doi.org/10.3390/genes15121619
- Citations
- 1
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- University of South Dakota