ACE Loss Drives Renal Cell Carcinoma Growth and Invasion by Modulating AKT-FOXO1
Our findings investigated the roles and mechanisms of ACE in ccRCC. ACE inhibits the growth and metastasis of ccRCC cells in vitro and in vivo by promoting FOXO1 expression, which is the downstream target of PI3K-AKT pathway. Thus, this research suggests that ACE may be a promising target for new therapeutic strategy in ccRCC.
Authors
- Lulu Mao (ORCID: https://orcid.org/0009-0005-6661-7665)
- Chao Lü (ORCID: https://orcid.org/0000-0002-2118-8888)
- Chuang Yue
- Lei Yin (ORCID: https://orcid.org/0000-0002-6983-2337)
- Chengxun Lv
- Wei Cao (ORCID: https://orcid.org/0000-0003-4105-012X)
- Kai Xu (ORCID: https://orcid.org/0000-0002-6761-1020)
- Rui Yin (ORCID: https://orcid.org/0000-0002-2372-3952)
- Yin Chen
- Xiaokai Shi
- Zonglin Wu
Institutions
- Ruijin Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Shandong Provincial Hospital (CN)
- Changzhou No.2 People's Hospital (CN)
- Yangpu Hospital of Tongji University (CN)
Publication Details
- Journal
- Biologics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/btt.s485178
- Citations
- 3
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.70