Exploring the relaxation effects of Coptis chinensis and berberine on the lower esophageal sphincter: potential strategies for LES motility disorders
This study demonstrates that C. chinensis and berberine significantly promote LES relaxation, primarily through potassium channel activation. These findings provide a foundation for further investigation of these compounds' potential therapeutic applications in esophageal motility disorders, such as achalasia.
Authors
- Ting-I Lin
- Ching-Wen Liu
- Ming‐Shiang Wu (ORCID: https://orcid.org/0000-0002-1940-6428)
- Li-Ching Chang (ORCID: https://orcid.org/0000-0002-8710-0471)
- Liwei Lin (ORCID: https://orcid.org/0000-0001-7083-624X)
- I-Chun Lin (ORCID: https://orcid.org/0000-0001-6775-8914)
- Ching‐Chung Tsai (ORCID: https://orcid.org/0000-0002-9862-6575)
- W H Koh
Institutions
- E-Da Hospital (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Min-Hwei College of Health Care Management (TW)
- National Taiwan University Hospital (TW)
- I-Shou University (TW)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12906-024-04720-x
- Citations
- 1
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.46
Funders
- E-Da Hospital