Effect of acute bisphenol A toxicity on behavior and locomotor activity of Danio rerio

The results of evaluating the effects of acute exposure of Danio rerio to bisphenol A solutions on behavioral traits and locomotor activity using the open field test are presented. It was found that bisphenol A in the exposure aquariums resulted in impaired movement, hyperactivity, increased mucus secretion, and increased gill cover movements. Fish not exposed to the pollutant in the open field test spent most of their time near the edges of the aquarium, exhibiting moderate exploratory activity. Bisphenol A in the open field test at concentrations greater than 1 mg/l caused a significant increase in mean locomotor speed (to 11.1 cm/s) and a decrease in inactivity time (to 9.9 s). The indices of locomotor activity in Danio rerio, significantly altered by bisphenol A, showed a clear concentration-effect relationship: for inactivity time in the inner circle, R² = 0.6765, and in the outer ring, R² = 0.7140; for movement speed in the inner circle, R² = 0.4365, and in the outer ring, R² = 0.4011. Acute toxicity of bisphenol A resulted in the development of anxiety-like behavior in fish, characterized by hyperactivity, increased exploratory activity, and decreased thigmotaxis.