Efficacy of androgen receptor signaling inhibitors in combination with androgen deprivation therapy for castration-sensitive metastatic prostate cancer: a retrospective analysis in a Japanese cohort
Adding ARSI to ADT extended the time to CRPC but did not significantly affect OS. However, it potentially suppressed the short-term risk of death in high-risk subgroups. This study highlights the need for further research to explore the characteristics of Japanese patients with metastatic prostate cancer in whom upfront ARSIs are effective.
Authors
- Toshiyuki Kamoto (ORCID: https://orcid.org/0000-0002-7728-289X)
- Takeshi Sasaki (ORCID: https://orcid.org/0000-0002-2458-5686)
- Shoichi Kimura (ORCID: https://orcid.org/0000-0002-8603-7781)
- Katsuki Tsuchiyama (ORCID: https://orcid.org/0000-0003-2691-0953)
- Takahiro Inoue (ORCID: https://orcid.org/0000-0001-8586-784X)
- Shinichiro Higashi
- Naoki Terada (ORCID: https://orcid.org/0009-0005-1082-6089)
- Atsuro Sawada (ORCID: https://orcid.org/0000-0003-4833-1709)
- Minekatsu Taga (ORCID: https://orcid.org/0000-0002-1767-9799)
Institutions
- University of Fukui (JP)
- University of Miyazaki (JP)
- Mie University (JP)
Publication Details
- Journal
- International Journal of Clinical Oncology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1007/s10147-024-02670-5
- Citations
- 2
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- University of Fukui
- University of Miyazaki