Genomic analyses revealed low genetic variation in the intron-exon boundary of the doublesex gene within the natural populations of An. gambiae s.l. in Burkina Faso
These findings will guide the implementation of doublesex-targeted gene drives to support the current control tools in malaria elimination efforts. Our methods can be applied to efficiently monitor the evolution of any sequence of interest in a natural population via pooled amplicon sequencing, surpassing the need for WGS.
Authors
- Mahamadi Kientega (ORCID: https://orcid.org/0000-0002-1715-8459)
- Abdoul Azize Millogo (ORCID: https://orcid.org/0000-0003-3301-9149)
- Abdoulaye Diabaté (ORCID: https://orcid.org/0000-0002-9666-9395)
- B. J. Austin
- Franck Adama Yao (ORCID: https://orcid.org/0000-0001-8237-0360)
- Adrien Marie Gaston Bélem (ORCID: https://orcid.org/0000-0001-7405-1626)
- Nace Kranjc (ORCID: https://orcid.org/0000-0001-7720-8430)
- Ioanna Morianou (ORCID: https://orcid.org/0000-0002-3472-6032)
- Patric Stephane Epopa (ORCID: https://orcid.org/0000-0002-5806-6446)
- Nouhoun Traoré (ORCID: https://orcid.org/0000-0002-6050-8717)
- Honorine Kaboré (ORCID: https://orcid.org/0000-0003-1159-3174)
- O Zongo
Institutions
- University of East Anglia (GB)
- Norwich Research Park (GB)
- Nazi Boni University (BF)
- Institut de Recherche en Sciences de la Santé (BF)
- Imperial College London (GB)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12864-024-11127-y
- Citations
- 4
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Bill and Melinda Gates Foundation
- Wellcome Trust
- Open Philanthropy Project