β3-Adrenergic receptor antagonism improves cardiac and vascular functions but did not modulate survival in a murine resuscitated septic shock model
In an experimental murine model of resuscitated septic shock, β3-AR is resistant to desensitization and its inhibition improves cardiac and vascular function without affecting the short-term survival.
Authors
- Manon Durand (ORCID: https://orcid.org/0000-0003-4631-8009)
- Antoine Kimmoun (ORCID: https://orcid.org/0000-0002-5443-2074)
- Eugénie Hagimont
- Frances Yen-Potin
- Benjamin Glenn Chousterman (ORCID: https://orcid.org/0000-0002-9592-7014)
- Marc‐Damien Lourenco‐Rodrigues (ORCID: https://orcid.org/0000-0001-6572-1798)
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- French Clinical Research Infrastructure Network (FR)
- Défaillance Cardiovasculaire Aiguë et Chronique
- Université de Lorraine (FR)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s40635-024-00705-9
- Citations
- 1
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Université de Lorraine