CPNE7 promotes colorectal tumorigenesis by interacting with NONO to initiate ZFP42 transcription

Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death globally. Also, there is still a lack of effective therapeutic strategies for CRC patients owing to a poor understanding of its pathogenesis. Here, we analysed differentially expressed genes in CRC and identified CPNE7 as a novel driver of colorectal tumorigenesis. CPNE7 is highly expressed in CRC and negatively correlated with patients' prognosis. Upregulation of CPNE7 promotes proliferation and metastasis of cancer cells in vitro and in vivo, and vice versa. Mechanistically, CPNE7 interacts with NONO to initiate ZFP42 transcription, thus promoting CRC progression. Moreover, ZFP42 knockdown inhibits tumor cell proliferation and migration while promoting apoptosis. Notably, delivery of CPNE7 shRNA or the small molecule gramicidin, which blocks the interaction between CPNE7 and NONO, hinders tumor growth in vivo. In conclusion, our findings demonstrate that the CPNE7-NONO-ZFP42 axis promotes colorectal tumorigenesis and may be a new potential therapeutic target.

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Publication Details

Journal
Cell Death and Disease
Published
2024-12-18
DOI
https://doi.org/10.1038/s41419-024-07288-z
Primary Topic
RNA modifications and cancer
Type
article
Field-Weighted Citation Impact
0.00

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article

CPNE7 promotes colorectal tumorigenesis by interacting with NONO to initiate ZFP42 transcription

Shuiling Jin, Luyun He, Guanghua Wu, Benyu Liu et al.
1 links
Cell Death and Disease
RNA modifications and cancer
article

CPNE7 promotes colorectal tumorigenesis by interacting with NONO to initiate ZFP42 transcription

Shuiling Jin, Luyun He, Guanghua Wu, Benyu Liu, Zhao-Yuan Xu, Liangbo Zhao, Hao Xing, Xiangrui Zhang, Xiao Sun, Yanmei Yang, Hong Chen, Huimin Xie, Pei‐Wen Wang, Zhenzhen Chen, Chenying Hou
article en

Abstract

Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death globally. Also, there is still a lack of effective therapeutic strategies for CRC patients owing to a poor understanding of its pathogenesis. Here, we analysed differentially expressed genes in CRC and identified CPNE7 as a novel driver of colorectal tumorigenesis. CPNE7 is highly expressed in CRC and negatively correlated with patients' prognosis. Upregulation of CPNE7 promotes proliferation and metastasis of cancer cells in vitro and in vivo, and vice versa. Mechanistically, CPNE7 interacts with NONO to initiate ZFP42 transcription, thus promoting CRC progression. Moreover, ZFP42 knockdown inhibits tumor cell proliferation and migration while promoting apoptosis. Notably, delivery of CPNE7 shRNA or the small molecule gramicidin, which blocks the interaction between CPNE7 and NONO, hinders tumor growth in vivo. In conclusion, our findings demonstrate that the CPNE7-NONO-ZFP42 axis promotes colorectal tumorigenesis and may be a new potential therapeutic target.

Cell Death and DiseaseVol. 15(12)
Zhengzhou University (CN), Henan Academy of Sciences (CN), First Affiliated Hospital of Zhengzhou University (CN), Institute of Infection and Immunity (CA)
National Natural Science Foundation of China, Natural Science Foundation of Henan Province, National Key Research and Development Program of China
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Openalex Percentile: Top 79%
RNA modifications and cancer
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