Impact of pediatric continuous renal replacement therapy parameters on meropenem, piperacillin, and tazobactam pharmacokinetics: an <i>in vitro</i> model
The clearance of low protein-binding, low molecular weight antimicrobials increases with higher CRRT effluent flow rates, with modality-specific differences in clearance dynamics.
Authors
- Frantz Foissac (ORCID: https://orcid.org/0000-0002-9928-3404)
- Sihem Benaboud
- Saı̈k Urien (ORCID: https://orcid.org/0000-0002-1065-0600)
- Gabrielle Lui (ORCID: https://orcid.org/0000-0002-6529-0024)
- Mehdi Oualha (ORCID: https://orcid.org/0000-0002-0488-5948)
- Fabrice Lesage (ORCID: https://orcid.org/0000-0002-9272-8183)
- Steeve Rouillon
- Michaël Thy (ORCID: https://orcid.org/0000-0001-9366-505X)
- Naïm Bouazza (ORCID: https://orcid.org/0000-0002-2158-1399)
- Jean‐Marc Tréluyer (ORCID: https://orcid.org/0000-0002-2045-4742)
- Léo Froelicher Bournaud (ORCID: https://orcid.org/0009-0001-3950-7728)
- Floura Kecili
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Paris Cité (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Bichat-Claude-Bernard (FR)
Publication Details
- Journal
- Expert Opinion on Drug Metabolism & Toxicology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1080/17425255.2024.2443754
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Baxter International
- Société de Réanimation de Langue Française