Silencing PADI-2 induces antitumor effects by downregulating NF-κB, Nrf2/HO-1 and AKT1 in A549 lung cancer cells
Downregulation of PADI-2 attenuated the proliferation, migration, and invasion of A549 lung cancer cells by modulating the Nrf2/HO-1/AKT signaling pathway. It also increased senescence in A549 lung cancer cells via IL6 and p53 key regulators. These findings highlight the potential of PADI-2 as a therapeutic target in lung cancer treatment.
Authors
- Justyna Fert‐Bober (ORCID: https://orcid.org/0000-0002-2824-5056)
- Alia Sadiq (ORCID: https://orcid.org/0000-0003-3080-7991)
- Peter Chen (ORCID: https://orcid.org/0000-0002-5330-1718)
Institutions
- Cedars-Sinai Medical Center (US)
- Cedars-Sinai Smidt Heart Institute (US)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1016/j.intimp.2024.113830
- Citations
- 3
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.51
Funders
- Cedars-Sinai Medical Center