Copper-Catalyzed Domino Phosphorylation/Cyclization of <i>ortho</i>-Alkynylketones for Accessing Phosphorylated 1<i>H</i>-Isochromenes

An effective and economical copper-catalyzed approach for the synthesis of phosphorylated 1<i>H</i>-isochromenes is reported. This method is the first example of focus on ketone phosphonylation to establish a C-P bond and 6-<i>endo</i>-<i>dig</i> cyclization to construct a C-O bond between aryl- and alkyl-substituted alkynylketones and H-phosphinate esters, H-phosphites, and H-phosphine oxides, resulting in chemo- and regioselective phosphorylated 1<i>H</i>-isochromenes with moderate to excellent yields under smooth reaction conditions.