Recreational and Occupational Physical Activity and Risk of Adverse Events in Truncating <i>MYBPC3</i> Founder Variant Carriers
Overall exercise participation does not generally increase the risk of adverse events among <i>MYBPC3</i> founder variant carriers. Nonetheless, an increased risk of malignant ventricular arrhythmia was observed among those engaged in the highest quartile of high-dynamic sports, suggesting that high-level high-intensity exercise activities should be entertained with caution.
Authors
- Arthur A.M. Wilde (ORCID: https://orcid.org/0000-0002-0528-0852)
- Laurens P. Bosman (ORCID: https://orcid.org/0000-0002-7847-4607)
- Freyja H.M. van Lint (ORCID: https://orcid.org/0000-0002-1787-4519)
- Amand F. Schmidt (ORCID: https://orcid.org/0000-0003-1327-0424)
- Danny AJP van de Sande (ORCID: https://orcid.org/0000-0002-8553-5025)
- Rudolf A. de Boer (ORCID: https://orcid.org/0000-0002-4775-9140)
- Annette F. Baas
- Dennis Dooijes (ORCID: https://orcid.org/0000-0003-0312-5354)
- Folkert W. Asselbergs (ORCID: https://orcid.org/0000-0002-1692-8669)
- H T Jørstad (ORCID: https://orcid.org/0000-0003-3617-3256)
- Imke Christiaans (ORCID: https://orcid.org/0000-0001-5799-2344)
- Jan D.H. Jongbloed (ORCID: https://orcid.org/0000-0003-0663-404X)
- Ronald H. Lekanne Deprez (ORCID: https://orcid.org/0000-0003-4687-0186)
- Saskia N. van der Crabben (ORCID: https://orcid.org/0000-0001-8619-1511)
- J. Peter van Tintelen (ORCID: https://orcid.org/0000-0003-3854-6749)
- Anneline S.J.M. te Riele (ORCID: https://orcid.org/0000-0002-4694-4790)
- Fahima Hassanzada (ORCID: https://orcid.org/0009-0004-3987-9507)
- Bristi Miah
- M. Jansen (ORCID: https://orcid.org/0000-0002-0896-4440)
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Netherlands Heart Institute (NL)
- Amsterdam Neuroscience (NL)
- Health Data Research UK (GB)
- ERN GUARD-Heart (NL)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Circulation Genomic and Precision Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1161/circgen.124.004561
- Citations
- 3
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Dutch Cardiovascular Alliance
- National Institute for Health and Care Research
- British Heart Foundation
- University College London
- Fondation Leducq