Long-term prognosis of life of patients after primary and recurrent myocardial infarction: data from two Russian registries (LIS-3 and RIMIS)

Aim . To compare the long-term survival of patients after primary and recurrent myocardial infarction (MI) in the LIS-3 and RIMIS registries. Material and methods . The retrospective RIMIS registry included patients with acute transmural MI admitted to the emergency cardiology department of one of the Moscow vascular centers in 2017. A total of 214 patients were included, of which 23 people died in hospital and 191 people were included in the prospective registry part. Long-term vital status was assessed on average 6 years after discharge from hospital and was determined in 178 patients. The response rate was 93,19%. The prospective registry LIS-3 included all patients admitted to the Lyubertsy Regional Hospital with a diagnosis of acute coronary syndrome, of which 78 patients were discharged after confirmed MI in the first 9 months of 2014, and 164 patients were discharged after confirmed MI in the first 9 months of 2018. A total of 242 patients were included. Long-term vital status was determined in 207 patients. The response rate 85,5%. The median follow-up was 872 days. Comparative analysis of patient cohorts from the RIMIS and LIS-3 registries did not reveal any significant differences in the main demographic, anamnestic, and clinical parameters. The frequency of percutaneous coronary intervention in the acute stage of MI was higher in the RIMIS registry than in the LIS-3 registry (96,9 and 62,3%, respectively). Results . During the follow-up period, 31,4% of patients died in the RIMIS registry, and 20,8% of patients in the LIS-3 registry. Kaplan-Meier curves did not reveal any significant differences in patient survival in both registries. At the same time, in both registries, the long-term survival of patients after recurrent MI was significantly worse than that of patients who had a primary MI. Conclusion . Patients who had an acute MI, despite modern treatment in the acute stage, have a high residual risk of death. This is especially true for patients who had a recurrent MI.