NEW BIARYL DERIVATIVES OF DICLOFENAC DRUG: SYNTHESIS, MOLECULAR DOCKING AND THEIR BIOLOGICAL ACTIVITY STUDY AS ANTICANCER AND ANTIOXIDANT AGENTS

In this work, a series of diclofenac derivatives were synthesized via the Suzuki-Miyaura reaction and evaluated in vitro as anticancer and antioxidant agents. Structures of synthesized compounds were characterized by FT- IR, 1H NMR, 13C NMR spectra, and elemental analysis. The products have been screened in vitro for their anticancer activity against both cell lines HdFn and MCF-7 as well as they were investigated for their antioxidant activity. The cytotoxicity assay results revealed that derivatives 3a and 3d exhibited good inhibition for cell lines MCF-7 with IC50 values 33.1 and 38.2 µM, respectively while 3a and 3c exhibited acceptable inhibition for HdFn with IC50 values 68.7 and 72.6µM, respectively compared to the Tamoxifine drug. Molecular docking study of the target compounds confirmed the results of the cytotoxicity test. In addition, results of the DPPH investigation revealed good antioxidant activity for derivatives 3a, 3c and 3d with inhibition percentages of 83.14, 82.42, and 78.16%, respectively compared to ascorbic acid. For citation: Abdul-Rida N.A., Mohammed K.T. New biaryl derivatives of diclofenac drug: synthesis, molecular docking and their biological activity study as anticancer and antioxidant agents. ChemChemTech [Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.]. 2024. V. 67. N 12. P. 47-53. DOI: 10.6060/ivkkt.20246712.7071.