STUDY OF THE EFFECT OF NANOSIZED BARIUM TITANATE IN CUBIC SYNGONY ON HEMOCOMPATIBILITY AND ANTIOXIDANT PROPERTIES

The development of the field of application of ceramic nanomaterials for medicine has recently been of significant interest. These include nanodispersed barium titanate powders, which exhibit antimicrobial and antifungal activity. They are considered as carriers of drugs, as well as biocompatible components of bone tissue. The search for new opportunities to realize the potential of nanodispersed barium titanate in biomedicine is an urgent task. The paper presents a method for the synthesis of nanosized barium titanate powder obtained by heat treatment at 800 °C in an air environment of sol-gel synthesis products. The resulting nanomaterial has a crystalline structure with cubic structure. According to electron microscopy, the powder particles are characterized by a polydisperse composition and are partially agglomerated. The results of energy dispersive analysis of the samples are presented. The particle size in the dispersion ranges from 50 nm to 250 nm, and the Scherrer crystallite size is 3.85 nm. The degree of hemolysis was assessed in vitro using fresh donor blood in the presence and absence of barium titanate nanoparticles. The hemolytic effect of barium titanate (>5%) manifests itself at a high concentration of powder (450 µl/ml) in the blood, which indicates the biocompatibility of nano-sized BaTiO3 up to the specified concentration. The effect of BaTiO3 concentration on free radical oxidation of lipids and antioxidant activity in blood serum was analyzed using the method of induced chemiluminescence. It has been established that at a concentration of 200 µl/ml BaTiO3 exhibits antioxidant activity, and at 400 µl/ml it has the ability to activate free radical oxidation of blood serum lipids. For citation: Ivanov K.V., Filimonova Yu. A., Agafonov A.V., Nazarov S.B. Study of the effect of nanosized barium titanate in cubic syngony on hemocompatibility and antioxidant properties. ChemChemTech [Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.]. 2024. V. 67. N 12. P. 6-14. DOI: 10.6060/ivkkt.20246712.7077.