Comparative Evaluation of the Preventive Effects of Citral, Silymarin, Thymoquinone, and Curcumin on 5-Fluorouracil-Induced Cardiac and Pulmonary Toxicity in Rats
Our study indicated that the natural compounds citral, silymarin, thymoquinone, and curcumin, when combined with 5-fluorouracil, could minimize the histopathological and biochemical changes caused by 5-fluorouracil treatment in the heart and pulmonary tissues likely via antioxidant mechanisms. These products can be useful and effective in chemotherapy patients by reducing the potential adverse effects of 5-fluorouracil administration.
Authors
- Nasrollah Ahmadi (ORCID: https://orcid.org/0000-0001-9306-0552)
- Saeed Nazıfı (ORCID: https://orcid.org/0000-0002-5501-1028)
- Mohammad Foad Noorbakhsh (ORCID: https://orcid.org/0000-0002-6983-0577)
- Ahmad Oryan (ORCID: https://orcid.org/0000-0003-1697-2376)
- Tohid Zahed (ORCID: https://orcid.org/0009-0006-1317-9582)
Institutions
- Shiraz University (IR)
Publication Details
- Journal
- Journal of pharmacopuncture
- Published
- 2024-12-18
- DOI
- https://doi.org/10.3831/kpi.2024.27.4.277
- Citations
- 1
- Primary Topic
- Nigella sativa pharmacological applications
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- Shiraz University