Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEWS pharmacokinetics study
A positive exposure-response relationship between vedolizumab trough concentrations and UC outcomes suggests that monitoring drug levels may be beneficial. While thiopurine did not influence vedolizumab levels, its withdrawal may necessitate higher vedolizumab trough concentrations to maintain remission.
Authors
- Sudarshan Paramsothy (ORCID: https://orcid.org/0000-0002-9097-6028)
- Rupert W. Leong (ORCID: https://orcid.org/0000-0001-5944-3488)
- Melissa Kermeen
- Viraj C. Kariyawasam (ORCID: https://orcid.org/0000-0003-2623-1336)
- Aviv Pudipeddi (ORCID: https://orcid.org/0000-0002-3664-2246)
- Thanaboon Chaemsupaphan (ORCID: https://orcid.org/0009-0001-3408-7277)
- Hui-Yu Lin (ORCID: https://orcid.org/0000-0003-0197-6075)
Institutions
- Siriraj Hospital (TH)
- Mahidol University (TH)
- Tan Tock Seng Hospital (SG)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.3748/wjg.v31.i2.101292
- Citations
- 2
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.10