Microenvironmental G protein‐coupled estrogen receptor‐mediated glutamine metabolic coupling between cancer‐associated fibroblasts and triple‐negative breast cancer cells governs tumour progression
Estrogen-activated GPER in CAFs enhances GLUL and LDHB expression via the cAMP/PKA/CREB signalling, facilitating glutamine production and utilization. Microenvironmental GPER-induced glutamine serves as a crucial mediator of metabolic coupling between CAFs and TNBC cells, boosting tumour progression by enhancing mitochondrial function. Targeting the glutamine metabolic coupling triggered by estrogen/GPER/GLUL signalling in CAFs is a promising therapeutic strategy for TNBC treatment.
Authors
- Manran Liu (ORCID: https://orcid.org/0000-0002-3898-6878)
- Zhiqiang Peng (ORCID: https://orcid.org/0000-0001-8130-162X)
- Hanzhi Dong
- Chunling Jiang (ORCID: https://orcid.org/0000-0002-1214-5325)
- Chongwu He (ORCID: https://orcid.org/0009-0006-4510-944X)
- Meixi Peng
- Liyan Liu
- Jiawei Xu (ORCID: https://orcid.org/0009-0008-5642-6373)
- Zhengkui Sun
- Bin Xu (ORCID: https://orcid.org/0000-0003-4993-0500)
- Yuan Qiu (ORCID: https://orcid.org/0000-0002-8997-4367)
- Xiaoqiang Zeng
- Tao Yu (ORCID: https://orcid.org/0009-0006-1036-9153)
- Yanxiao Huang
Institutions
- Nanchang University (CN)
- Jiangxi Provincial Cancer Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/ctm2.70131
- Citations
- 16
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Education Department of Jiangxi Province