Research on the Selective Extraction of Oxibendazole Residues in Animal‐Derived Food Using Molecularly Imprinted Polymers

To achieve specific adsorption-based sample preparation for the poorly soluble veterinary drug oxibendazole, this study employed 4-vinylpyridine as the functional monomer and conducted radical polymerization on the surface of functionalized silica nanoparticles to synthesize a surface molecularly imprinted polymer (OBZMIP). This OBZMIP exhibited good adsorption capacity for oxibendazole within 30 min, with its adsorption behavior conforming to the pseudo-second-order kinetic and Langmuir models, predicting a maximum adsorption capacity of 4.93 mg/g. After five adsorption-desorption cycles, the adsorption capacity remained unchanged, demonstrating excellent reusability. In a mixed system containing eight similar compounds, the selectivity coefficients ranged from 1.3 to 16.9, indicating outstanding specific recognition ability. Utilized as an adsorbent packing material for solid-phase extraction, the prepared OBZMIP demonstrated significantly high recovery rates in the extraction of oxibendazole from four distinct meat samples. Therefore, OBZMIP holds promising applications in the selective extraction of veterinary drug oxibendazole residues during the pretreatment of meat samples.