Lipopolysaccharide in Bile Promotes the Neutrophil Extracellular Traps-Induced Gallstone Formation by Activating the Gallbladder Immune Barrier
With the biliary dysbiosis, excessive LPS can invade the submucosa of the gallbladder, leading to chronic inflammation that recruits neutrophils to form NETs, which are ultimately expelled into bile, thereby promoting the formation of gallstones.
Authors
- Dongbo Xue (ORCID: https://orcid.org/0000-0001-9012-4805)
- Ziang Meng
- Liyi Wang (ORCID: https://orcid.org/0000-0002-9454-8872)
- Chenjun Hao (ORCID: https://orcid.org/0000-0003-2888-500X)
- Xuxu Liu (ORCID: https://orcid.org/0000-0001-5408-4746)
- Jingjing Yu (ORCID: https://orcid.org/0000-0002-8616-9389)
- Yi Zheng (ORCID: https://orcid.org/0000-0002-1585-7598)
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/itt.s495095
- Citations
- 14
- Primary Topic
- Gallbladder and Bile Duct Disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.87