Multiple Primary Cutaneous Plasmacytoma: Case Report with Review of the Literature

Background: Primary cutaneous plasmacytoma (PCP) is an uncommon variant of cutaneous B-cell lymphoma characterized by the presence of plasma cells in the skin. It represents a localized manifestation of plasma cell neoplasia, typically presenting as a solitary lesion on the skin. The rarity of PCP poses diagnostic and management challenges, with limited clinical data available, making the establishment of standardized treatment guidelines difficult. Case Report: A 55-year-old male with no prior medical history presented with multiple purplish nodules on the back, shoulder, and face, evolving over six months. Histologic and immunohistochemical analyses confirmed cutaneous plasmacytoma. Staging investigations supported the primary nature of the disease, leading to the decision of therapeutic abstention with regular monitoring. Discussion: Primary cutaneous plasmacytoma involves the clonal proliferation of plasma cells in the skin. While multiple primary cutaneous plasmacytomas are rare, they have typically been treated with chemotherapy, with or without radiotherapy. In the presented case, therapeutic abstention was chosen. This decision suggests that certain indolent forms of PCP may not require immediate chemotherapy.