Proteomic characterization of regenerated cartilage following knee joint distraction; a human case-study
Histologically, knee joint distraction-regenerated cartilage showed less glycosaminoglycans and disorganized collagen compared to native cartilage. However, mass-spectrometry has no major differences in extracellular matrix protein abundance, with proteomic clues suggesting protein translation regulation as a potential mechanism for regeneration.
Authors
- Guus van den Akker (ORCID: https://orcid.org/0000-0002-7071-1487)
- Laura Peeters (ORCID: https://orcid.org/0000-0001-5631-3784)
- Liesbeth M. C. Jutten (ORCID: https://orcid.org/0000-0002-8013-4919)
- Tim J. M. Welting (ORCID: https://orcid.org/0000-0001-8081-4466)
- Mandy J. Peffers (ORCID: https://orcid.org/0000-0001-6979-0440)
- Roderick H.M.J. Stassen
- Marjolein M. J. Caron (ORCID: https://orcid.org/0000-0001-5316-9211)
- James Anderson (ORCID: https://orcid.org/0000-0003-0489-7997)
- Jessica Steijns (ORCID: https://orcid.org/0009-0000-7860-4419)
- Tim A. E. J. Boymans (ORCID: https://orcid.org/0000-0002-6047-9581)
- Pieter J. Emans (ORCID: https://orcid.org/0000-0001-9370-5525)
- DANIEL JOHN GREEN (ORCID: https://orcid.org/0000-0003-3226-2921)
- Andy Cremers
Institutions
- University of Liverpool (GB)
- Maastricht University (NL)
Publication Details
- Journal
- Connective Tissue Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1080/03008207.2024.2440716
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Horserace Betting Levy Board
- Dutch Arthritis Association