Acetic acid-catalyzed synthesis of 1,5-disubstituted 1,2,3-triazoles under azide-free conditions
An environmentally-friendly and safe method has been developed to synthesize 1,5-disubstituted 1,2,3-triazoles containing difluoromethyl fragments, which can be obtained from readily available 2,2-difluoroarylethylamines under azide-free conditions.
Authors
- Jiuling Li
- Xinyu Jia
- Qiangguo Yang
- Jiakang Guo
- Qianhui Ren
- Taichen Liu
- Kai Wei
- Zheng-Hui Kang
Institutions
- Guiyang Medical University (CN)
- Pingdingshan University (CN)
- Chinese Academy of Sciences (CN)
- Guangxi Normal University (CN)
- Shanghai Institute of Materia Medica (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1039/d4qo02118e
- Citations
- 1
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.25