Novel Acylhydrazones Based on 1-Decylisatins and Girard Reagent T Possessing Antimicrobial Activity
By the reaction of new 1-decyl substituted isatin derivatives with Girard reagent T novel ammonium salts were obtained. These compounds display a moderate antimicrobial activity against gram-positive Staphylococcus aureus and Bacillus cereus bacterial strains with low hemotoxicity. Study of the influence of the structure of substituents in the heterocycle aromatic fragment on the self-assembly process and antimicrobial activity may indirectly indicate that the antimicrobial action of amphiphilic ammonium compounds based on the isatin scaffold is different from classical cationic surfactants.
Authors
- Anton V. Il’in (ORCID: https://orcid.org/0000-0002-2706-9898)
- Marina Ye. Kadomtseva (ORCID: https://orcid.org/0000-0002-9547-5564)
- В. Ф. Миронов (ORCID: https://orcid.org/0000-0002-4198-3774)
- Zukhra Shaihutdinova (ORCID: https://orcid.org/0009-0008-5713-4137)
- Alexandra D. Voloshina (ORCID: https://orcid.org/0000-0002-3540-8554)
- Andrei V. Bogdanov (ORCID: https://orcid.org/0000-0002-2483-4742)
- Tatiana N. Pashirova (ORCID: https://orcid.org/0000-0002-2001-1570)
Institutions
- Kazan Federal University (RU)
- A.E. Arbuzov Institute of Organic and Physical Chemistry (RU)
Publication Details
- Journal
- Russian Journal of General Chemistry
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1134/s1070363224110331
- Primary Topic
- Chemical Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00