Hydrogels based on natural polymers structured with propylene glycol diepoxide for drug delivery

The article presents the conditions of synthesis and the results of characterization of the obtained gelatin and gelatin-alginate hydrogels structured with polypropylene glycol diepoxide. The swelling in water, saline, and model exudate was studied, and the gel fraction and tensile strength of the synthesized samples were determined. The regularities of saturation with drugs and their release into model environments were obtained. The potential use of these materials for transdermal drug delivery is considered.

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Publication Details

Journal
Chemistry Technology and Application of Substances
Published
2024-12-01
DOI
https://doi.org/10.23939/ctas2024.02.176
Primary Topic
Hydrogels: synthesis, properties, applications
Type
article
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article

Hydrogels based on natural polymers structured with propylene glycol diepoxide for drug delivery

О. V. Maikovych, С. М. Варваренко, Nataliya Nosova, A. V. Hnyp et al.
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Chemistry Technology and Application of Substances
Hydrogels: synthesis, properties, applications
article

Hydrogels based on natural polymers structured with propylene glycol diepoxide for drug delivery

О. V. Maikovych, С. М. Варваренко, Nataliya Nosova, A. V. Hnyp, N. М. Bykartyk, Yu. V. Cherkas
article en

Abstract

The article presents the conditions of synthesis and the results of characterization of the obtained gelatin and gelatin-alginate hydrogels structured with polypropylene glycol diepoxide. The swelling in water, saline, and model exudate was studied, and the gel fraction and tensile strength of the synthesized samples were determined. The regularities of saturation with drugs and their release into model environments were obtained. The potential use of these materials for transdermal drug delivery is considered.

Chemistry Technology and Application of SubstancesVol. 7(2)
Clean water and sanitation
Openalex Percentile: Top 85%
Hydrogels: synthesis, properties, applications
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