Synthesis and Biological Properties of Hybrid Compounds Based on Nitrogen-Containing Heterocycles and 1,5-Disubstituted 3,7-Diazabicyclo[3.3.1]nonan-9-ones
The reaction of aromatic aldehydes and 3-(heteryl)methyl-4-methoxybenzaldehydes with 1,5-disubstituted 3,7-diazabicyclo[3.3.1]nonan-9-ones afforded 2-aryl(hetaryl)-5,7-dimethyl-1,3-diazaadamantane-6-ones. 3-(Heteryl)methyl-4-methoxybenzaldehydes were obtained by alkylation of nitrogen-containing heterocycles (N1-functionalized uracil and 5-halouracils, N3-functionalized 6-methylpyrimidin- and quinazolin-4(3H)-ones, benzotriazole, quinoline, benzoxazole) with 3-chloromethyl-4-methoxylbenzaldehyde. Antibacterial and fungicidal properties of the synthesized compounds were studied.
Authors
- H. А. Panosyan (ORCID: https://orcid.org/0000-0001-8311-6276)
- Anna Sukiasyan (ORCID: https://orcid.org/0009-0003-9716-2777)
- M. S. Safaryan (ORCID: https://orcid.org/0000-0003-2973-1088)
- A.A. Mnatsakanyan
- S. G. Israelyan (ORCID: https://orcid.org/0009-0000-8088-1060)
- Artur A. Hambardzumyan (ORCID: https://orcid.org/0000-0001-9526-7768)
- A. S. Sargsyan (ORCID: https://orcid.org/0000-0001-7249-233X)
- K. A. Gevorkyan (ORCID: https://orcid.org/0000-0003-3604-6038)
- A. D. Harutyunyan (ORCID: https://orcid.org/0000-0002-8320-0942)
- S. P. Gasparyan (ORCID: https://orcid.org/0000-0003-2341-724X)
- Roza Madoyan (ORCID: https://orcid.org/0009-0003-0875-9302)
- H.A. Karapetyan
- M. Yu. Danghyan (ORCID: https://orcid.org/0000-0001-7703-1591)
- M. R. Hakobyan (ORCID: https://orcid.org/0009-0001-4527-3913)
- А. А. Harutyunyan (ORCID: https://orcid.org/0000-0003-0641-5453)
Institutions
- Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry (AM)
- National Academy of Sciences of Armenia (AM)
Publication Details
- Journal
- Russian Journal of General Chemistry
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1134/s107036322411001x
- Citations
- 2
- Primary Topic
- Synthesis and Reactions of Organic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.50