Alkylation Reaction of Functionally Substituted 2-Hydrazine-1-carbothioamides with Some Unsaturated and Aryl Halides and Biological Activity of the Synthesized Compounds

The reaction of 2-[1-(4-methyl-5,5-R1,R2-2-oxo-2,5-dihydrofuran-3-yl)ethylidene]­hydrazine-1-carbothioamides with allyl and propargyl bromides in the presence of a catalytic amount of sodium methylate afforded the corresponding S-derivatives. The reaction with 2-bromoacetophenone under similar conditions afforded the corresponding dihydrothiazoles, 5,5-disubstituted 4-methyl-3-(1-{[4-phenylthiazol-2(3H)-ylidene]hydrazono}ethyl)furan-2(5H)-ones. The antiradical and anticholinesterase properties of the synthesized compounds were studied. It was found that they possess moderate antiradical and high antibutyrylcholinesterase activities.