Mesenchymal Stem Cells and Their Derived Exosomes Mitigated Hepatic Cirrhosis in Rats by Altering the Expression of miR-23b and miR-221.
hUCB-MSCs and their derived exosomes ameliorated liver cirrhosis by anti-inflammatory and anti-fibrotic effects besides modulation of autophagy. The exosomes had a better improvement effect either alone or combined with hUCB-MSCs, as proved by improvement in liver function tests, and molecular, histopathological, and immunohistochemical profiles.
Authors
- Walaa Samy (ORCID: https://orcid.org/0000-0002-1542-1727)
- Amira Ebrahim Alsemeh (ORCID: https://orcid.org/0000-0002-5203-0784)
- Samia Hussein (ORCID: https://orcid.org/0000-0002-7407-1608)
- Tarek Khamis (ORCID: https://orcid.org/0000-0003-4722-2666)
- Doaa M. Abdullah (ORCID: https://orcid.org/0000-0001-6409-9079)
- Somia H. Abd‐Allah
Institutions
- Zagazig University (EG)
Publication Details
- Journal
- PubMed
- Published
- 2024-11-01
- DOI
- https://doi.org/10.30476/ijms.2023.99524.3159
- Citations
- 3
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.86