Intranasal Dexmedetomidine for the Management of Preoperative Anxiety-Related Insomnia: A Randomized, Three-Blinded, Clinical Trial Compared with Lorazepam and Placebo
Both 2.5 μg/kg intranasal Dex and 2 mg oral lorazepam effectively improved sleep quality in patients with preoperative anxiety-related insomnia. While both treatments were comparable in maintaining sleep, intranasal Dex was more effective in initiating sleep and enhancing daytime functionality than lorazepam.
Authors
- Maolin Zhong (ORCID: https://orcid.org/0000-0001-7363-5478)
- Wen‐Yi Yang (ORCID: https://orcid.org/0000-0003-1279-0866)
- Weidong Liang (ORCID: https://orcid.org/0000-0002-8290-3216)
- Xin Liu (ORCID: https://orcid.org/0000-0002-2207-4356)
- Li Chen (ORCID: https://orcid.org/0000-0001-9556-9053)
- Lifeng Wang (ORCID: https://orcid.org/0000-0002-9334-6873)
- Jun Wei (ORCID: https://orcid.org/0000-0003-3633-7150)
- Wen Zeng (ORCID: https://orcid.org/0000-0002-8064-3203)
- Zhi-jian Lin
- Kuan-Ta Huang
- Hong-Bo Liu
Institutions
- Gannan Medical University (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/dddt.s487463
- Citations
- 3
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Natural Science Foundation of Jiangxi Province