Association of Serum 25-Hydroxyvitamin D Level with the Grades of Hepatic Encephalopathy in Cirrhotic Patients

Background: Liver cirrhosis is the final phase of the hepatic fibrosis process, defined as a diffuse disruption of the normal architecture of the liver with fibrosis and nodule formation and it is one of the major cause of morbidity and mortality throughout the world. Hepatic encephalopathy (HE) is one of the complications of cirrhosis that identified in up to 55% of patients. The etiology of HE is complex and multifactorial. Vitamin D deficiency is more common in cirrhosis and associated with neuropsychiatric abnormalities and systemic inflammation as well as infection thereby giving rise to the development of HE. Objectives: This study aimed to evaluate the serum 25- Hydroxyvitamin D level in liver cirrhosis patient with or without hepatic encephalopathy and its relation with grades of hepatic encephalopathy. Materials and Methods: An observational cross-sectional study was carried out in the Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka from December 2019 to August 2020. Patients who met the selection criteria were counselled and finally 54 were included in the study among them 27 had hepatic encephalopathy where 27 had not. Serum 25-Hydroxyvitamin D level was estimated by chemiluminescence immunoassay (CLIA) in our Biochemistry department. All data were presented as mean ± SD & analyzed by SPSS (version 20). Qualitative data were analyzed by Chi-square test & quantitative data were analyzed by student’s t-test. Statistically significance of serum 25- Hydroxyvitamin D level among the grades of hepatic encephalopathy will be detected by ANOVA test. A statistically significant result was considered when p value less than 0.05. Result: Among 54 cirrhotic patients, age ranged from 20 to 72 years and the mean age was 50.2 ± 13.1 years. The Child-Pugh score and MELD score were negatively correlate with mean 25-Hydroxyvitamin D level. The mean level of 25-Hydroxyvitamin D ...