Exploratory Research for HIF-1α Overexpression Tumor Antigen in the Activation of Dendritic Cells and the Potent Anti-Tumor Immune Response
Our findings demonstrate that tumor antigens enriched with HIF-1α may encompass tumor-specific antigens capable of stimulating DC activation, thereby enhancing T cell proliferation and cytotoxicity. These results provide support for the further advancement of HIF-1α enriched tumor antigens in preclinical and clinical investigations pertaining to tumor treatment.
Authors
- Fei Lin (ORCID: https://orcid.org/0000-0003-2321-889X)
- Zhiyin Wang
- Qingjiang Mo
- Zhiqiang Lin (ORCID: https://orcid.org/0000-0003-1834-2060)
- Guoqiang Wang (ORCID: https://orcid.org/0000-0002-2549-6212)
- Jinjin Zhao (ORCID: https://orcid.org/0000-0002-3886-829X)
- Guoan Zhao (ORCID: https://orcid.org/0000-0003-1266-7374)
- Haiguang Zhang (ORCID: https://orcid.org/0000-0002-3318-3072)
- Yilin Zhao (ORCID: https://orcid.org/0000-0003-2587-0400)
- Guangmeng Lv
Institutions
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Cancer Management and Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/cmar.s482363
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.29