Analysis of the Relationship of Biomarkers of Cytogenetic and Psychophysiological Status of Personnel under Conditions of the Combined Influence of Occupational Factors

Background: Analysis of the Relationship of biomarkers of Cytogenetic and Psychophysiological Status (CGS and PPS) of personnel under conditions of the combined influence of occupational factors. Material and methods: CGS was determined using a non-invasive Buccal Micronucleus Cytome Assay (BMCA) and determination of the accumulation index of cytogenetic damage and the level of cytogenetic stress. PPS of personnel was determined in accordance with MR 2.2.9.84 – 2015 FMBA of Russia and the Health-Test program. Results: People with average and high levels of psychophysiological adaptation have a low level of cytogenetic damages. Also, in the group with a high accumulation index of cytogenetic damages a low level of psychophysiological adaptation was determined. Conclusion: An increased level of cytogenetic damages has been established in people with a low level of psychophysiological adaptation. Taking into account the literature data, we can assume an indirect dependence of the cytogenetic status of the organism on its psychophysiological adaptation, which may be due to hormonal imbalance and the induction of oxidative stress.