Plasma p-tau217 in Alzheimer’s disease: Lumipulse and ALZpath SIMOA head-to-head comparison
Plasma phosphorylated-tau217 (p-tau217) has been shown to be one of the most accurate diagnostic markers for Alzheimer's disease. No studies have compared the clinical performance of p-tau217 as assessed by the fully automated Lumipulse and single molecule array (SIMOA) AlZpath p-tau217. The study included 392 participants, 162 with Alzheimer's disease, 70 with other neurodegenerative diseases with CSF biomarkers and 160 healthy controls. Plasma p-tau217 levels were measured using the Lumipulse and ALZpath SIMOA assays. The ability of p-tau217 assessed by both techniques to discriminate Alzheimer's disease from other neurodegenerative diseases and controls was investigated using receiver operating characteristic analyses. The p-tau217 levels measured by the two techniques demonstrated a strong correlation, showing a consistent relationship with CSF p-tau181 levels. In head-to-head comparison, Lumipulse and SIMOA showed similar diagnostic accuracy for differentiating Alzheimer's disease from other neurodegenerative diseases [area under the curve (AUC) 0.952, 95% confidence interval (CI) 0.927-0.978 versus 0.955, 95% CI 0.928-0.982, respectively] and healthy controls (AUC 0.938, 95% CI 0.910-0.966 and 0.937, 95% CI 0.907-0.967 for both assays). This study demonstrated the high precision and diagnostic accuracy of p-tau217 for the clinical diagnosis of Alzheimer's disease using fully automated or semi-automated techniques.
Authors
- Andrea Zancanaro
- Andrea Rizzardi (ORCID: https://orcid.org/0009-0008-4568-0018)
- Cristina Mordenti
- José Contador (ORCID: https://orcid.org/0000-0002-9692-1570)
- Andrea Pilotto (ORCID: https://orcid.org/0000-0003-2029-6606)
- Sebastian Palmqvist (ORCID: https://orcid.org/0000-0002-9267-1930)
- Diego Bertoli (ORCID: https://orcid.org/0000-0002-5264-7821)
- Chiara Tolassi (ORCID: https://orcid.org/0009-0006-8741-1313)
- Virginia Quaresima (ORCID: https://orcid.org/0000-0001-8858-3236)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Salvatore Caratozzolo (ORCID: https://orcid.org/0000-0001-5579-9081)
- Duilio Brugnoni (ORCID: https://orcid.org/0000-0001-9420-9961)
- Kaj Blennow
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Giovanni De Santis
- Alice Galli (ORCID: https://orcid.org/0009-0009-7804-5106)
- Marc Suárez‐Calvet (ORCID: https://orcid.org/0000-0002-2993-569X)
- Alessandro Padovani (ORCID: https://orcid.org/0000-0002-0119-3639)
- Chiara Trasciatti
- Nicholas J. Ashton
Institutions
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- Lund University (SE)
- Sahlgrenska University Hospital (SE)
- Brescia University (US)
- Sorbonne Université (FR)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Pasqual Maragall Foundation (ES)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Skåne University Hospital (SE)
- Banner Sun Health Research Institute (US)
- Institut du Cerveau (FR)
- The Memory Clinic (US)
- Banner Alzheimer’s Institute
- University College London (GB)
- University of Brescia (IT)
- University of Gothenburg (SE)
Publication Details
- Journal
- Brain
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1093/brain/awae368
- Citations
- 42
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 13.72
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Eli Lilly and Company
- Biogen
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- Prothena
- GHR Foundation
- André Losch Fondation
- European Commission
- Fondazione Cariplo
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Eisai
- Hjärnfonden
- Knut och Alice Wallenbergs Stiftelse
- Novo Nordisk
- Vetenskapsrådet
- Alzheimerfonden
- Siemens Healthineers
- H. Lundbeck A/S
- Grifols
- Julius Clinical
- UK Dementia Research Institute
- Associazione Italiana Ricerca Alzheimer
- Olav Thon Stiftelsen
- National Institutes of Health
- Parkinsonfonden
- Horizon 2020 Framework Programme
- Avid Radiopharmaceuticals
- HORIZON EUROPE Framework Programme
- European Research Council
- Instituto de Salud Carlos III
- UCLH Biomedical Research Centre
- National Institute on Aging
- H2020 Marie Skłodowska-Curie Actions