Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric, Version 3.2024, NCCN Clinical Practice Guidelines In Oncology
Multigene panel testing has allowed for the detection of a growing number of inherited pathogenic/likely pathogenic variants in people at high risk of cancer, including endometrial cancer (EC). Hereditary syndromes associated with EC include Lynch syndrome, PTEN hamartoma tumor syndrome, and Peutz-Jeghers syndrome. This manuscript provides the latest recommendations from the NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric on the screening and management of EC in patients at high risk for these syndromes, as well as the advantages and limitations of multigene panel testing. This manuscript also describes recent updates to these guidelines regarding de-implementation of colon cancer screening in individuals with CHEK2 pathogenic/likely pathogenic variants, based on the most up-to-date evidence regarding the association between CHEK2 pathogenic/likely pathogenic variants and colon cancer risk.
Authors
- Katie Lang
- Jennifer M. Weiss (ORCID: https://orcid.org/0000-0002-4927-2133)
- Matthew B.B. Yurgelun (ORCID: https://orcid.org/0000-0002-6184-9273)
- Susan Gustafson
- Rachel Hodan (ORCID: https://orcid.org/0000-0003-2887-4079)
- Michael J. Hall (ORCID: https://orcid.org/0000-0003-4515-3409)
- Heather Hampel (ORCID: https://orcid.org/0000-0001-7558-9794)
- Zachariah H. Foda (ORCID: https://orcid.org/0000-0002-3591-8482)
- Mariana Moreno Prats
- Arnold J. Markowitz (ORCID: https://orcid.org/0000-0002-5449-9623)
- David Shibata (ORCID: https://orcid.org/0000-0002-5670-423X)
- Andrea R. Hagemann (ORCID: https://orcid.org/0000-0002-3484-0046)
- Susan Darlow
- Bryson W. Katona (ORCID: https://orcid.org/0000-0001-8186-9119)
- Xavier Llor (ORCID: https://orcid.org/0000-0002-6259-185X)
- Carol A. Burke (ORCID: https://orcid.org/0000-0002-7225-0696)
- Benjamin Swanson (ORCID: https://orcid.org/0009-0007-3887-9128)
- Kaitlyn Kelly
- AnnMarie Kieber‐Emmons
- Peter P. Stanich (ORCID: https://orcid.org/0000-0002-6844-640X)
- Brittany M. Szymaniak (ORCID: https://orcid.org/0000-0001-8336-5010)
- N. Jewel Samadder (ORCID: https://orcid.org/0000-0001-7182-5569)
- Sara Pirzadeh‐Miller (ORCID: https://orcid.org/0000-0001-6731-378X)
- William M. Grady (ORCID: https://orcid.org/0000-0002-0129-7809)
- Nawal Kassem (ORCID: https://orcid.org/0000-0002-4582-9600)
- Darryl Outlaw (ORCID: https://orcid.org/0000-0001-9618-6935)
- Gregory Idos (ORCID: https://orcid.org/0000-0002-6068-4139)
- Seth Felder (ORCID: https://orcid.org/0000-0001-6975-8379)
- Mariana Niell‐Swiller
- Katherine M Clayback
- Georgia L. Wiesner (ORCID: https://orcid.org/0000-0001-8897-7008)
- Samir Gupta (ORCID: https://orcid.org/0000-0003-4192-5002)
- Lisen Axell
- Zeenat Diwan
- Daniel C. Chung (ORCID: https://orcid.org/0000-0002-6965-1907)
- Jeanna Welborn
- Sonia S. Kupfer
- Nora Joseph
- Francis M. Giardiello
- Mary A. Dwyer
- Lee-may Chen
Institutions
- Fox Chase Cancer Center (US)
- Roswell Park Comprehensive Cancer Center (US)
- Barnes-Jewish Hospital (US)
- City Of Hope National Medical Center (US)
- St. Jude Children's Research Hospital (US)
- Cleveland Clinic (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Memorial Sloan Kettering Cancer Center (US)
- University of Tennessee Health Science Center (US)
- Breast Cancer Research Foundation (US)
- University of Utah (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- UC San Diego Health System (US)
- Huntsman Cancer Institute (US)
- Cancer Institute (WIA) (IN)
- Susan Thompson Buffett Foundation (US)
- WinnMed (US)
- Yale Cancer Center (US)
- Moffitt Cancer Center (US)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Southwestern Medical Center (US)
- Jewish Hospital (US)
- University of Wisconsin Carbone Cancer Center (US)
- Sidney Kimmel Cancer Center (US)
- University Hospitals Seidman Cancer Center (US)
- Duke Medical Center (US)
- University of Colorado Cancer Center (US)
- Dana-Farber Brigham Cancer Center (US)
- Smilow Cancer Hospital (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center
- Moores Cancer Center
- University of Chicago Medicine Comprehensive Cancer Center
- UCLA Jonsson Comprehensive Cancer Center
- Vanderbilt-Ingram Cancer Center
- Stanford Cancer Institute
- Duke Cancer Institute
- Fred and Pamela Buffett Cancer Center
- UC Davis Comprehensive Cancer Center
- Harold C. Simmons Comprehensive Cancer Center
- O'Neal Comprehensive Cancer Center
- National Comprehensive Cancer Network
- Indiana University (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- The University of Texas Southwestern Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2024-12-01
- DOI
- https://doi.org/10.6004/jnccn.2024.0061
- Citations
- 76
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 32.30