The immune health assessment technique of the elderly population and its application and promotion in the prevention and treatment of common aged diseases

Immunosenescence refers to the phenomenon in which the human immune system gradually degrades in structure and function with the increase of age. The mechanism of human immunosenescence is complex, involving the systematic changes of multiple immune cell populations and molecular markers. At present, there is a significant lack of data on the characteristics of immunosenescence in the whole population in China, which limits the comprehensive understanding of the law of immunosenescence in the elderly population and the formulation of effective coping strategies. To accurately assess the immune health status of the elderly population, the integrated application of multiomics technology and informatics technology can help scientists to understand the changes of the immune system with age in detail and depict the characteristic map of immunosenescence, which not only helps to understand the molecular mechanism of aging but also provides potential targets for the development of intervention measures for age-related diseases. Moreover, it can provide a scientific basis for the health management of the elderly population, help formulate more effective prevention and treatment strategies, and provide a solid scientific basis for the formulation of public health policies in our country in the future.

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Publication Details

Journal
Journal of Aging and Rehabilitation
Published
2024-12-01
DOI
https://doi.org/10.1097/jagr.0000000000000021
Primary Topic
Single-cell and spatial transcriptomics
Type
article
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The immune health assessment technique of the elderly population and its application and promotion in the prevention and treatment of common aged diseases

Ling‐bing Meng, Qing Li
2 links
Journal of Aging and Rehabilitation
Single-cell and spatial transcriptomics
article

The immune health assessment technique of the elderly population and its application and promotion in the prevention and treatment of common aged diseases

Ling‐bing Meng, Qing Li
article en

Abstract

Immunosenescence refers to the phenomenon in which the human immune system gradually degrades in structure and function with the increase of age. The mechanism of human immunosenescence is complex, involving the systematic changes of multiple immune cell populations and molecular markers. At present, there is a significant lack of data on the characteristics of immunosenescence in the whole population in China, which limits the comprehensive understanding of the law of immunosenescence in the elderly population and the formulation of effective coping strategies. To accurately assess the immune health status of the elderly population, the integrated application of multiomics technology and informatics technology can help scientists to understand the changes of the immune system with age in detail and depict the characteristic map of immunosenescence, which not only helps to understand the molecular mechanism of aging but also provides potential targets for the development of intervention measures for age-related diseases. Moreover, it can provide a scientific basis for the health management of the elderly population, help formulate more effective prevention and treatment strategies, and provide a solid scientific basis for the formulation of public health policies in our country in the future.

Journal of Aging and RehabilitationVol. 1(4)
Army Medical University (CN), Southwest Hospital (CN), Beijing Tsinghua Chang Gung Hospital (CN), Tsinghua University (CN)
Good health and well-being
Openalex Percentile: Top 79%
Single-cell and spatial transcriptomics
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