Mapping Simulated ECG to Early Acute Kidney Injury Based on Electrolyte Disturbances

Background: Acute kidney injury (AKI) leads to blood electrolyte imbalances, affecting cardiac electrophysiology.However, the specific ECG features associated with early-stage AKI and its underlying ionic mechanism remain unclear.Methods: Serum K + and Ca 2+ levels in mice were measured within 12 hours post-AKI onset.These values were input as parameters into cardiac computational model to simulate action potential duration (APD) at cellular level and ECG at one-dimensional level respectively.Results: Silico study shows that low serum K + leads to increased R and S wave amplitudes during the 1hour post-AKI phase.In the 12-hour post-AKI phase, high serum K + causes flattened QRS.The T wave peak, corresponding to APD plateau phase, is delayed.Conclusion: The relationship between ECG features and AKI development within 12 hours is built based on blood K + and Ca2+ measurements.ECG can serve as a valuable clinical indicator for identifying cardiac electrophysiological changes in the early stages of AKI.