In-silico Model to Study the Role of Anomalous Origin of Coronary Artery in Sudden Cardiac Death

Sudden cardiac death in athletes is often related to anomalies in coronary-arteries origin, which affect the coronary perfusion.These anomalies seems not associated with the processes inducing the sudden cardiac death, since no symptoms are observed even during intense physical activities.To analyze the physical processes induced by anomalous coronary artery origins an experimental setup has been proposed by Mousavi 2024 [1], reproducing the human ascending aorta, aortic sinuses of Valsalva, left, and right coronary arteries, including a first-hand trileaflet bioprosthetic aortic valve.To understand accurately the hydrodynamic processes, aortic pressures, coronary pressures, and coronary flows has been measured simultaneously, allowing us to evaluate coronary resistance and to setup numerical simulations useful for the modeling of the fluid dynamics in the whole coronary arteries.Piecewise-constant resistance parametrization is used in Windkessel-type models to derive coronary outflow.To test the capability of this approach, it is used to evaluate the boundary conditions of numerical simulations of the hydrodynamics in the Valsalva Sinuses and in the coronary arteries, showing an accurate simulation of the hydrodynamic structures, supporting the use of Windkessel-type outflow boundary conditions, based on pressure measurements.