In-Silico Investigation of the Right and Left Atrial Contributions to the P-Wave Morphology in ECG of Healthy and Atrial Fibrillation Patients

Atrial fibrillation (AF), the most common arrhythmia, can be diagnosed from altered morphology of P-waves in patient's ECG.This study aims to evaluate contributions of electrical activity in the right (RA) and left atria (LA) to the P-wave in both control and AF patients.Two 3D torso computational models generated from highresolution CT patient scans were used for in-silico simulations of bi-atrial, RA-only and LA-only electrical activity and resulting 12-lead ECG.Body surface potentials were recorded in standard 12-lead ECG positions using pseudo-bidomain equations and finite element methods.We demonstrate that RA contributes nearly twice as much to P-wave morphology as LA and has a significantly greater impact on other indices.