A Novel Computational Model of the Zebrafish Atrial Action Potential and Intracellular Calcium Transient

The zebrafish has emerged as a valuable experimental model for studying cardiac electrophysiology and arrhythmias, yet there are no detailed computational models specific to its atrial action potential (AP) and intracellular calcium (Ca 2+ ) transient (CaT).We present a novel zebrafish-specific model, integrating experimental data from microelectrode and optical mapping recordings in the adult heart.We used a combination of experimental measurements and simulations to calibrate the model and validate it against additional experimental data.The model successfully reproduces experimentally observed atrial AP and CaT under various physiological conditions, offering a valuable tool for future work involving disease modelling, drug screening, and the investigation of cardiac arrhythmias.