Catalyzing Pharmacogenomic Analysis for Informing Pain Treatment (C-PAIN): A Randomized Trial of Preemptive CYP2D6 Genotyping in Cancer Palliative Care
The primary study outcome will be composite pain intensity during the first 45 days after an index opioid prescription for codeine, tramadol, or hydrocodone. Safety will be assessed by comparing opioid-related adverse event rates between the two study arms. Secondary outcomes will include rates of hospitalization/emergency room visits, cumulative morphine equivalents received, and type of first opioid prescribed.
Authors
- Kiang-Teck J Yeo (ORCID: https://orcid.org/0000-0002-4708-8420)
- Peter H. O’Donnell (ORCID: https://orcid.org/0000-0003-2650-0049)
- Samuel L. Volchenboum (ORCID: https://orcid.org/0000-0001-9863-851X)
- Theodore Karrison (ORCID: https://orcid.org/0009-0009-8641-5111)
- Anish Choksi (ORCID: https://orcid.org/0000-0002-9461-6054)
- Everett E. Vokes (ORCID: https://orcid.org/0000-0002-8645-8068)
- Randall W. Knoebel (ORCID: https://orcid.org/0000-0002-0166-4955)
- Mark J. Ratain (ORCID: https://orcid.org/0000-0002-0938-4392)
- Russell Z. Szmulewitz (ORCID: https://orcid.org/0000-0002-1444-3617)
- Malcolm W. Jack (ORCID: https://orcid.org/0000-0001-8067-2234)
- Youngwoo Cho (ORCID: https://orcid.org/0000-0002-1902-0381)
Institutions
- Chicago Department of Public Health (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- University of Chicago Medical Center (US)
- PharmacoGenetics (China) (CN)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jpr.s488416
- Citations
- 1
- Primary Topic
- Pain Management and Opioid Use
- Type
- article
- Field-Weighted Citation Impact
- 0.64
Funders
- National Institutes of Health