Breathing orchestrates synchronization of sleep oscillations in the human hippocampus
Nested sleep oscillations, emerging from asynchronous states in coordinated bursts, are critical for memory consolidation. Whether these bursts emerge intrinsically or from an underlying rhythm is unknown. Here, we show a previously undescribed respiratory-driven oscillation in the human hippocampus that couples with cardinal sleep oscillations. Further, breathing promotes nesting of ripples in slow oscillations, together suggesting that respiration acts as an intrinsic rhythm to coordinate synchronization of sleep oscillations, providing a unique framework to characterize sleep-related respiratory and memory processes.
Authors
- Mahmoud Omidbeigi
- Christopher Cyr (ORCID: https://orcid.org/0000-0002-4467-3333)
- Stephan Schuele (ORCID: https://orcid.org/0000-0003-3261-7120)
- Joshua M. Rosenow (ORCID: https://orcid.org/0000-0001-7726-2496)
- Christina Zelano (ORCID: https://orcid.org/0000-0002-7917-4147)
- Andrew Sheriff (ORCID: https://orcid.org/0000-0003-0434-7522)
- Katherina Hauner (ORCID: https://orcid.org/0009-0008-5648-4979)
- Vivek Sheel Sagar (ORCID: https://orcid.org/0000-0003-1301-2687)
- Gregory Lane (ORCID: https://orcid.org/0000-0003-3101-0722)
- Guangyu Zhou (ORCID: https://orcid.org/0000-0003-0897-6465)
- Justin B. Morgenthaler
Institutions
- Northwestern University (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1073/pnas.2405395121
- Citations
- 10
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 3.43
Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders
- National Institute of Neurological Disorders and Stroke