Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort

Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. EPIC questionnaire data were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority to assess long-term dietary mycotoxin exposure (expressed as μg/kg body weight/day) and then relate them to the risk of hepatocellular carcinoma (HCC) (n = 255) and biliary tract cancers (n = 273). Analyses were conducted using multivariable Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (95% CI). Key food groups contributing to mycotoxin exposure were cereals and cereal-based products, vegetables, non-alcoholic beverages (including fruit juices) and fruits. Estimated intake of deoxynivalenol (DON) and its derivatives was positively associated with HCC risk (HRT3vsT1: 1.90, 95% CI: 1.18-3.05, p-trend <0.01). No statistically significant associations were found for the other mycotoxins. Further research to confirm our observations and investigate potential underlying mechanisms of these compounds is warranted. These data may provide evidence of HCC risks associated with higher dietary intake levels of DON, which has not yet been classified as a human carcinogen.

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Journal
PLoS ONE
Published
2024-12-16
DOI
https://doi.org/10.1371/journal.pone.0315561
Citations
7
Primary Topic
Mycotoxins in Agriculture and Food
Type
article
Field-Weighted Citation Impact
4.20

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article

Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort

Andrea Altieri, Alicia K. Heath, Bernadette Chimera, Carine Biessy et al.
7 citations
PLoS ONE
Mycotoxins in Agriculture and Food
4.20
article

Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort

Andrea Altieri, Alicia K. Heath, Bernadette Chimera, Carine Biessy, Jesús Castilla, Marthe De Boevre, Guri Skeie, Michael Korenjak, Esther Molina‐Montes, Emily Sonestedt, Antonio Agudo, Pauline Frénoy, Fie Langmann, Matthias Bernd Schulze, Isabelle P. Oswald, Liesel Claeys, Ana Jiménez-Zabala, Magritt Brustad, Lisa Padroni, Ghislaine Scélo, Mazda Jenab, Sabina Sieri, Giovanna Masala, Geneviève Nicolas, Sarah De Saeger, Jiří Zavadil, Inarie Jacobs, Domenico Palli, Francesca Romana Mancini, Julien Vignard, Corinne Casagrande, Elom K. Aglago, Inge Huybrechts, Marc J. Gunter, Christina C. Dahm, Béatrice Fervers, José María Huerta, Mårten Werner, Paolo Vineis, Xuan Ren, Maria Santucci de Magistris
article en
7 citations

Abstract

Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. EPIC questionnaire data were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority to assess long-term dietary mycotoxin exposure (expressed as μg/kg body weight/day) and then relate them to the risk of hepatocellular carcinoma (HCC) (n = 255) and biliary tract cancers (n = 273). Analyses were conducted using multivariable Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (95% CI). Key food groups contributing to mycotoxin exposure were cereals and cereal-based products, vegetables, non-alcoholic beverages (including fruit juices) and fruits. Estimated intake of deoxynivalenol (DON) and its derivatives was positively associated with HCC risk (HRT3vsT1: 1.90, 95% CI: 1.18-3.05, p-trend <0.01). No statistically significant associations were found for the other mycotoxins. Further research to confirm our observations and investigate potential underlying mechanisms of these compounds is warranted. These data may provide evidence of HCC risks associated with higher dietary intake levels of DON, which has not yet been classified as a human carcinogen.

PLoS ONEVol. 19(12)
European Food Safety Authority (IT), Université Toulouse III - Paul Sabatier (FR), Inserm (FR), Universidad de Granada (ES), École Nationale Vétérinaire de Toulouse (FR), University of Potsdam (DE), Université Fédérale de Toulouse Midi-Pyrénées (FR), Lund University (SE), Université de Versailles Saint-Quentin-en-Yvelines (FR), Aarhus University (DK), Université Paris-Saclay (FR), Basque Government (ES), Institut Gustave Roussy (FR), Bellvitge University Hospital (ES), Ghent University (BE), Instituto de Salud Pública de Navarra (ES), Institut d'Investigació Biomédica de Bellvitge (ES), Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR), Ministry of Health (ES), Toxicologie Alimentaire (FR), Centre de recherche en Epidémiologie et Santé des Populations (FR), Centre Léon Bérard (FR), Institut Català d'Oncologia (ES), Instituto de Investigación Biosanitaria de Granada (ES), Cancer Research Institute Ghent (BE), Piedmont Reference Center for Epidemiology and Cancer Prevention (IT), Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES), Fondazione IRCCS Istituto Nazionale dei Tumori (IT), German Institute of Human Nutrition (DE), Centre international de recherche sur le cancer (FR), Imperial College London (GB), Northern Norway Regional Health Authority (NO), UiT The Arctic University of Norway (NO), Umeå University (SE)
Compagnia di San Paolo, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Deutsches Zentrum für Herz-Kreislaufforschung, Danish Cancer Society Research Center, Cancer Research UK, National Institute for Health and Care Research, Imperial College London, European Commission, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, ZonMw, Bundesministerium für Bildung und Forschung, Cancerfonden, Ministerie van Volksgezondheid, Welzijn en Sport, Ligue Contre le Cancer, Vetenskapsrådet, Fondation de France, Consiglio Nazionale delle Ricerche, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Wereld Kanker Onderzoek Fonds, Heidelberger Zentrum für Personalisierte Onkologie Deutsches Krebsforschungszentrum In Der Helmholtz-Gemeinschaft, Medical Research Council, Rijksinstituut voor Volksgezondheid en Milieu, NIHR Imperial Biomedical Research Centre, School of Public Health, Imperial College London, Inserm Transfert, HORIZON EUROPE Innovative Europe
Openalex Percentile: Top 6%
Mycotoxins in Agriculture and Food
4.20
DOIOpen Access PDFOpenAlex
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